Background: In the general population, reported levels of oxidative stress and antioxidant potential seem to vary.\r\nThe aim of this study was to investigate the levels of oxidant status markers in relation to estimated glomerular\r\nfiltration rate (eGFR) and albuminuria in Japanese population.\r\nMethods: Data were analyzed from 8335 individuals who underwent a general health screening test. For the\r\nestimation of albuminuria, urinary albumin-to-creatinine ratio (UAER) was calculated. Oxidant status was determined\r\nby assessing derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP).\r\nResults: After adjusting for age, high blood pressure, depressor agent use, CRP, smoking status, multivariate logistic\r\nregression analysis showed that the lowest eGFR quartile was associated negatively with the top d-ROM quartile in\r\nmen (odds ratio 0.78 [95% CI 0.62-0.98, P = 0.034]) and the highest UAER was associated with the top d-ROM in\r\nmen (odds ratio 1.68) [95% CI 1.35-2.10, P < 0.001]. In addition, both the first eGFR quartile and the fourth UAER\r\nquartile showed significant positive association with low BAP levels in men, but not in women.\r\nConclusions: Among men who underwent general health screening, lower eGFR and increased albuminuria was\r\nnegatively and positively, respectively, associated with higher oxidative stress levels, whereas both conditions were\r\npositively associated with lower antioxidant potential levels.
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